DAMGO|78123-71-4|-陌孚医药/Medlife

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DAMGO

目录号: PL08079 纯度: ≥99%

CAS No. :78123-71-4

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中文名称	DAMGO
中文别名	L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺
英文名称	DAMGO
英文别名	L-Phenylalaninamide,L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Na-methyl-;(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide;DAMGO;DAGO;Dagol;DAMGE;glyol;Tertiapin LQ;DAMPGO;H-Tyr-D-Ala(Me)Phe-NH-CH2-OH;NIH 10891;RX 783006;Tyr-D-Ala-Gly-(methyl)Phe-Gly-ol;Tyr-D-Ala-Gly-MePhe-Gly-ol;Tyr-D-Ala-Gly-MePhe-NH-(CH2)2OH;Tyr-D-Ala-Gly-N-methylphenylalanine-glycinol
Cas No.	78123-71-4
分子式	C₂₆H₃₅N₅O₆
分子量	513.59
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	DAMGO 是一种选择性的 μ-阿片受体 (μ-OPR) 激动剂，K_d 值为 3.46 nM。
生物活性	DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a K d of 3.46 nM for native μ-OPR.
性状	Solid
IC50 & Target[1][2]	Kd: 3.46±0.84 nM (native μ-OPR)
体外研究(In Vitro)	DAMGO (1-10 μM) significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression. DAMGO (1 μM) effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DAMGO (i.v., 0.5-2 mg/kg) can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	Y-{d-Ala}-G-{Me-Phe}-G-ol
Sequence	Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol
参考文献	[1]. FEBS Lett. 1995 Jan 2;357(1):93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops. [2]. Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12(6):492-500.

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL (194.71 mM)DMSO : 33.33 mg/mL (64.90 mM; Need ultrasonic)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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