Trimebutine|39133-31-8|(曲美布汀)-陌孚医药/Medlife

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Trimebutine (Synonyms: 曲美布汀)

目录号: PL08006

CAS No. :39133-31-8

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中文名称	Trimebutine
中文别名	曲美布汀;曲美布汀碱;3,4,5-三甲氧基苯甲酸 (2-二甲胺基-2-苯基)丁酯;曲美布汀(曲美布汀碱);2-碘-4-硝基苯胺;Trimebutine 曲美布汀;黄霉素;马来酸曲美布汀;曲美布汀标准品;三甲丁酯;三甲丁酯系统适应性 EP标准品;3,4,5-三甲氧基苯甲酸2-(二甲基氨基)-2-苯基丁酯;曲美布汀中间体;3,4,5-三甲氧基苯甲酸 2-(二甲氨基)-2-苯基丁酯
英文名称	Trimebutine
英文别名	trimebutine free base;TRIMEBUTIN;TRIMEBUTINE;3,4,5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL;3,4,5-TRIMETHOXYBENZOIC ACID 2-[DIMETHYLAMINO]-2-PHENYLBUTYL ESTER;2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL-3',4',5'-TRIMETHOXYBENZOATE;Trimebutine hydrochloride;TRIMEBUTINE3.4.5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL;3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester;Trimebutine base 0.97;2-(Dimethylamino)-2-phenylbutyl 3,4,5-Trimethoxybenzoate;Benzoic acid,3,4,5-trimethoxy-,2-(dimethylamino)-2-phenylbutyl ester (9CI);Trimebutine maleate;Trimebutino;Trimebutinum [INN-Latin];Trimebutino [INN-Spanish];Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester;Trimedat;Trimebutine [INN:BAN:DCF];2-Dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoat;C22H29NO5;LORDFXWUHHSAQU-UHFFFAOYSA-N;Trimebutine maleate salt;Trimebut
Cas No.	39133-31-8
分子式	C₂₂H₂₉NO₅
分子量	387.47
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Trimebutine是阿片受体激动剂，有抗毒蕈碱活性。

生物活性

Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53.
[2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7.

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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