DAMGO TFA|950492-85-0|-陌孚医药/Medlife

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DAMGO TFA

目录号: PL08038 纯度: ≥99%

CAS No. :950492-85-0

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中文名称	DAMGO TFA
英文名称	DAMGO TFA
英文别名	DAMGO;DAGO;glyol;Dagol;DAMGE;Tyr-ala-gly-(nme)phe-gly-ol;RX 783006;Tyr-D-Ala-Gly-MePhe-Gly-ol;H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol;[3H]DAMGO;L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-;Tyr-D-Ala-;Tyr-D-Ala-Gly-MePhe-Gly(ol);Tyr-D-Ala-Gly-NMe-Phe-Gly-ol;Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol;Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol;Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol;Ala(2)-mephe(4)-gly;DAMGO (TFA)
Cas No.	950492-85-0
分子式	C₂₈H₃₆F₃N₅O₈
分子量	627.61
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	DAMGO TFA 是一种选择性的 μ-阿片受体 (μ-OPR) 激动剂，K_d 值为 3.46 nM。
生物活性	DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a K d of 3.46 nM for native μ-OPR.
性状	Solid
体外研究(In Vitro)	DAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression. DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	Y-{d-Ala}-G-{Me-Phe}-G-ol
Sequence	Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol
参考文献	[1]. FEBS Lett. 1995 Jan 2;357(1):93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops. [2]. Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12(6):492-500.

溶解度数据	In Vitro: H₂O : 125 mg/mL (199.17 mM; Need ultrasonic)配制储备液

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