β-Casomorphin, bovine|72122-62-4|(β-Casomorphin-7 (bovine); Bovine β-casomorphin-7)-陌孚医药/Medlife

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β-Casomorphin, bovine (Synonyms: β-Casomorphin-7 (bovine); Bovine β-casomorphin-7)

目录号: PL08069 纯度: ≥99%

CAS No. :72122-62-4

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中文名称	β-Casomorphin, bovine
英文名称	β-Casomorphin, bovine
英文别名	L-Isoleucine,L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-;BETA-CASOMORPHIN BOVINE;H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-Oh;TYR-PRO-PHE-PRO-GLY-PRO-ILE;β-Casomorphin (bovine);Alzheimer's peptide;BETA-CASOMORPHIN (BOVINE);YPFPGPI;β-Casomorphin, bovine
Cas No.	72122-62-4
分子式	C₄₁H₅₅N₇O₉
分子量	789.92
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情	β-casomorphin, bovine (β-Casomorphin-7 (bovine) ) 是阿片 (opioid) 活性的多肽，与阿片受体结合的 IC₅₀ 值为 14 μM。
生物活性	β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC 50 of 14 μM in an Opioid receptors binding assay.
性状	Solid
IC50 & Target[1][2]	IC50: 14 μM (Opioid receptor)
体外研究(In Vitro)	β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment. β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels. β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC. β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	β-Casomorphin, bovine (7.5×10 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats. β-Casomorphin, bovine (7.5×10 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-Casomorphin, bovine (7.5×10 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats. β-Casomorphin, bovine (7.5×10 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye
SequenceShortening	YPFPGPI
Sequence	Tyr-Pro-Phe-Pro-Gly-Pro-Ile
参考文献	[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.

溶解度数据	In Vitro: DMSO : 100 mg/mL (126.60 mM; Need ultrasonic)H₂O : ≥ 50 mg/mL (63.30 mM)

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