Naloxonazine dihydrochloride|880759-65-9|-陌孚医药/Medlife

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Naloxonazine dihydrochloride

目录号: PL08024

CAS No. :880759-65-9

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中文名称	Naloxonazine dihydrochloride
中文别名	纳洛肼二盐酸盐
英文名称	Naloxonazine dihydrochloride
英文别名	Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, [(5a)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone,dihydrochloride, (5a)-;bis[(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone hydrate dihydrochloride;Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, [(5a)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene];NALOXONAZINE DIHYDROCHLORIDE
Cas No.	880759-65-9
分子式	C₃₈H₄₂N₄O₆^.₂[HCl]
分子量	723.69
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Naloxonazine dihydrochloride 是一种特异性的 μ-opioid receptor 拮抗剂，IC₅₀ 为 5.4 nM。Naloxonazine dihydrochloride 也具有抗利什曼原虫活性。
生物活性	Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC 50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity.
性状	Solid
IC50 & Target[1][2]	μ Opioid Receptor/MOR 5.4 nM (IC50)
体外研究(In Vitro)	Naloxonazine is relatively stable in solution. Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM. Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection. Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ICR mi
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Chien CC, et al. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicol Lett. 2012 Jul 7;212(1):61-5. [2]. Hahn EF, et al. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 1982 Sep 20-27;31(12-13):1385-8.

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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