Tyr-Gly-Gly-Phe-Met-OH|58569-55-4|(蛋氨酸脑啡肽; Met-Enkephalin; Methionine enkephalin; Metenkefalin)-陌孚医药/Medlife

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Tyr-Gly-Gly-Phe-Met-OH (Synonyms: 蛋氨酸脑啡肽; Met-Enkephalin; Methionine enkephalin; Metenkefalin)

目录号: PL08077 纯度: ≥98%

CAS No. :58569-55-4

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中文名称	Tyr-Gly-Gly-Phe-Met-OH
中文别名	甲硫氨酸脑啡肽;蛋氨酸-脑啡呔;[MET5]脑啡肽;蛋氨酸脑啡肽;甲硫氨酸-脑啡肽;酪氨酰甘氨酰-甘氨酰-苯丙氨酰-蛋氨酸
英文名称	Tyr-Gly-Gly-Phe-Met-OH
英文别名	1-5-Adrenorphin (human)(9CI);H-Tyr-Gly-Gly-Phe-Met-OH;2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid;Tyr-Gly-Gly-Phe-Met;1-5-Adrenorphin (human);H-Tyr(1)-Gly(2)-Gly(3)-Phe(4)-Met(5)-OH;Lupex;Tyr-Gly-Gly-Phe-Met-OH;YGGFM;N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionine;METENKEFALIN;9JEZ9OD3AS
Cas No.	58569-55-4
分子式	C₂₇H₃₅N₅O₇S
分子量	573.66
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor)，可调控人类免疫功能，抑制肿瘤生长。
生物活性	Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
性状	Solid
IC50 & Target[1][2]	Opioid Receptor.
体外研究(In Vitro)	Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	YGGFM
Sequence	Tyr-Gly-Gly-Phe-Met
参考文献	[1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9.

溶解度数据	In Vitro: DMSO : ≥ 40 mg/mL (69.73 mM)H₂O : 6.67 mg/mL (11.63 mM; Need ultrasonic)

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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