BW-180C (Synonyms: [D-Ala2, D-Leu5]-Enkephalin; DADLE)
目录号: PL08072 纯度: ≥99%
CAS No. :63631-40-3
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中文名称
BW-180C
中文别名
(D-丙2,D-亮5)-脑啡肽;(D-丙2)-D-亮脑啡肽
英文名称
BW-180C
英文别名
D-Leucine,L-tyrosyl-D-alanylglycyl-L-phenylalanyl-;DADLE;H-Tyr-D-Ala-Gly-Phe-D-Leu-Oh;BW-180;D-Leu5>nekephalin;TYR-D-ALA-GLY-PHE-D-LEU;TYR-D-ALA-GLY-PHE-D-LEU ACOH H2O;YAGFL;BW-180C
Cas No.
63631-40-3
分子式
C29H39N5O7
分子量
569.65
包装储存
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
产品详情
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) 是水溶性的多肽类阿片受体 (Opioid Receptor) 激动剂。
生物活性
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) is a water soluble Opioid Receptor peptide agonist.
性状
Solid
IC50 & Target[1][2]
Opioid Receptor
体外研究(In Vitro)
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) significantly inhibits cellular transcription in SH-SY5Y cells without causing cell injury. Following recovery for 72 h without BW-180C in primary neurons, the transcriptional activity fully resumes. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay-tbl">
体内研究(In Vivo)
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) protects against I-R injury in hepatocytes, but not in the sinusoidal endothelial cells of the liver in rats. GPT levels are significantly lower in the BW-180C group as compared to those of the Control group, but the serum levels of HA are not different between the two groups. The concentrations of MDA of the liver tissue are significantly lower in the BW-180C group than in the Control group. BW-180C (DADLE)-induced analgesia is mediated by the stimulation of both mu- and delta-opioid receptors. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
参考文献
[1]. Jie Tian, et al. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Res. 2014 May 27;1565:1-7.
[2]. Kousyou Yamanouchi, et al. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat. J Surg Res. 2003 Sep;114(1):72-7.
溶解度数据
In Vitro: DMSO : ≥ 300 mg/mL (526.64 mM)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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