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Norbinaltorphimine dihydrochloride

(Synonyms: nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride)

目录号: PL08045 纯度: N/A

Norbinaltorphimine dihydrochloride是一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。

CAS No. :113158-34-2

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中文名称	Norbinaltorphimine dihydrochloride
英文名称	Norbinaltorphimine dihydrochloride
英文别名	nor-Binaltorphimine dihydrochloride;Norbinaltorphimine Dihydrochloride Salt;nor-BNI dihydrochloride;Norbinaltorphimine dihydrochloride;NorbinaltorphimineDihydrochlorideSalt;Tox21_500806;LP00806;nor-Binaltorphimine dihydrochloride, solid;N 1771
Cas No.	113158-34-2
分子式	C₄₀H₄₅Cl₂N₃O₆
分子量	734.71
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Norbinaltorphimine dihydrochloride是一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。

产品详情	Norbinaltorphimine dihydrochloride是一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。
生物活性	Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist.
性状	Solid
IC50 & Target[1][2]	κ opioid receptor
体外研究(In Vitro)	Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Birch PJ, et al. Norbinaltorphimine: antagonist profile at kappa opioid receptors. Eur J Pharmacol. 1987 Dec 15;144(3):405-8. [2]. Flax SM, et al. Effect of norbinaltorphimine on ??-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology (Berl). 2015 Sep;232(17):3193-201.

溶解度数据	In Vitro: DMSO : 100 mg/mL (136.11 mM; Need ultrasonic)配制储备液

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[1]. Birch PJ, et al. Norbinaltorphimine: antagonist profile at kappa opioid receptors. Eur J Pharmacol. 1987 Dec 15;144(3):405-8.
[2]. Flax SM, et al. Effect of norbinaltorphimine on ??-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology (Berl). 2015 Sep;232(17):3193-201.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Norbinaltorphimine dihydrochloride

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