Endomorphin 1 acetate

目录号: PL08046 纯度: ≥99%
Endomorphin 1 acetate,一种高度选择性的,高亲和力的 μ-opioid 受体激动剂 (Ki: 1.11 nM),对 kappa3结合位点具有高亲和力,Ki 值为 20 到 30 nM 之间。Endomorphin 1 acetate 具有镇痛特性。
CAS No. :1276123-71-7
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中文名称
Endomorphin 1 acetate
英文名称
Endomorphin 1 acetate
英文别名
L-Phenylalaninamide, L-tyrosyl-L-prolyl-L-tryptophyl-, acetate (1:1);Endomorphin 1 (acetate);MS-31055;CS-0617499;HY-P0185A;1276123-71-7
Cas No.
1276123-71-7
分子式
C36H42N6O7
分子量
670.75
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
详情描述
Endomorphin 1 acetate,一种高度选择性的,高亲和力的 μ-opioid 受体激动剂 (Ki: 1.11 nM),对 kappa3结合位点具有高亲和力,Ki 值为 20 到 30 nM 之间。Endomorphin 1 acetate 具有镇痛特性。
产品详情
Endomorphin 1 acetate,一种高度选择性的,高亲和力的 μ-opioid 受体激动剂 (Ki: 1.11 nM),对 kappa3结合位点具有高亲和力,Ki 值为 20 到 30 nM 之间。Endomorphin 1 acetate 具有镇痛特性。
生物活性
Endomorphin 1 acetate, a high affinity, highly selective agonist of the μ-opioid receptor (K i : 1.11 nM), displays reasonable affinities for kappa 3 binding sites, with K i value between 20 and 30 nM. Endomorphin 1 acetate has antinociceptive properties.
性状
Solid
IC50 & Target[1][2]
μ Opioid Receptor/MOR 1.11 nM (Ki)
体外研究(In Vitro)
Endomorphin 1 acetate inhibits Forskolin (HY-15371) (1 μM) stimulated cyclic AMP formation with a pIC50 value of 8.03 in In CHOμ cells.
Endomorphin 1 (1-10 μM) acetate increases interleukin-8 secretion in Caco-2 cells.
Endomorphin 1 (1 μM) acetate inhibits excitatory transmission in adult rat substantia gelatinosa neurons.
has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Endomorphin 1 (i.c.v.) acetate shows antinociceptive properties in mice, with an ED 50 value of 6.16 nM.
Endomorphin 1 (50 μg/kg, i.v., rats) acetate alleviates myocardial ischemia/reperfusion injury (MIRI) by inhibiting the inflammatory response.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
参考文献
[1]. Goldberg IE, et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13.
[2]. Tseng LF. The antinociceptive properties of endomorphin-1 and endomorphin-2 in the mouse. Jpn J Pharmacol. 2002 Jul;89(3):216-20.
溶解度数据
In Vitro: DMSO : 125 mg/mL (186.36 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Goldberg IE, et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13.
[2]. Tseng LF. The antinociceptive properties of endomorphin-1 and endomorphin-2 in the mouse. Jpn J Pharmacol. 2002 Jul;89(3):216-20.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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