Riboflavin Tetrabutyrate 是具有抗氧化和脂质过氧化物去除活性的亲脂性黄素衍生物。

Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

Solid

Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction. has not independently confirmed the accuracy of these methods. They are for reference only.

Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver . has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Tahara K, et al. Effect of riboflavin and riboflavin 2,3,4,5-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8.
[2]. Okuno E, et al. Effect of chronic administration of riboflavin 2,3,4,5-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in the rat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42.

In Vitro: DMSO : ≥ 100 mg/mL (152.27 mM)配制储备液