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HTHQ

目录号: PL10907 纯度: ≥99%

HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) 是一种强力的亲脂性酚类抗氧化剂。HTHQ 通过与活性氧 (ROS) 直接反应并清除 ROS 以形成更稳定的自由基而具有很强的抗氧化活性。

CAS No. :148081-72-5

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中文名称	HTHQ
中文别名	1-O-己基-2,3,5-三甲基氢化喹啉
英文名称	HTHQ
英文别名	Phenol,4-(hexyloxy)-2,3,6-trimethyl-;1-O-Hexyl-2,3,5-trimethylhydroquinone;1-O-n-hexyl-2,3,5-trimethylhydroquinone;3-Hydroxy-6-hexyloxy-1.2.4-trimethyl-benzol;4-Hexyloxy-2,3,6-trimethyl-phenol;DSSTox_CID_697;HTHQ;HTHQ-2,3,5;HX-1171;4-Hexyloxy-2,3,6-triMethylphenol;4-(Hexyloxy)-2,3,6-triMethyl-phenol;4-(Hexyloxy)-2,3,6-trimethylphenol;HX 1171;Phenol, 4-(hexyloxy)-2,3,6-trimethyl-;70BK60I8RP;C15H24O2;4-hexoxy-2,3,6-trimethylphenol;DSSTox_RID_75742;DSSTox_GSID_20697;BCP19301;Tox21_301245;DB1216
Cas No.	148081-72-5
分子式	C₁₅H₂₄O₂
分子量	236.35
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) 是一种强力的亲脂性酚类抗氧化剂。HTHQ 通过与活性氧 (ROS) 直接反应并清除 ROS 以形成更稳定的自由基而具有很强的抗氧化活性。

产品详情

生物活性

HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging ROS to form more stable free radicals.

性状

Solid

IC50 & Target[1][2]

ROS

体外研究(In Vitro)

HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.
HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Park HJ, et al. 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. Molecules. 2019 Mar 1;24(5). pii: E867.
[2]. Jung YR et al. Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats. Toxicol Res. 2010 Sep;26(3):193-201.

溶解度数据	In Vitro: DMSO : 100 mg/mL (423.10 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

HTHQ

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