Oxantel pamoate|68813-55-8|-陌孚医药/Medlife

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Oxantel pamoate

目录号: PL08791 纯度: ≥99%

CAS No. :68813-55-8

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中文名称	Oxantel pamoate
中文别名	Oxantel羟萘;酚嘧啶;酚嘧啶扑蛲灵;双羟萘酸奥克太尔;N-羟基琥珀酰亚胺酯;棕榈酸;含 4,4′-亚甲基双(3-羟基-2-萘甲酸) 的 1-甲基-2-(3-羟基苯乙烯基)-1,4,5,6-四氢嘧啶化合物;酚嘧啶扑蛲灵
英文名称	Oxantel pamoate
英文别名	Oxantel pamoate;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol;Oxantel embonate;EINECS 272-332-6;HMS2093L04;Oxantel pamoate (USAN);Telopar;Telopar (TN);UNII-UPY1D732T0;1-Methyl-2-(3-hydroxyphenylethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid)
Cas No.	68813-55-8
分子式	C₃₆H₃₂N₂O₇
分子量	604.65
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Oxantel pamoate 是一种广泛使用的驱虫剂，有效针对Trichuris muris 和钩虫。

生物活性

Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms.

性状

Solid

IC50 & Target[1][2]

Antiparasitic

体内研究(In Vivo)

The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED 50 s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED 50 s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus. has not independently confirmed the acc

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Keiser J, et al. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl Trop Dis. 2013;7(3):e2119.

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (82.69 mM)H₂O : 0.67 mg/mL (1.11 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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