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Lucanthone

(Synonyms: 硫蒽酮)

目录号: PL08805 纯度: ≥99%

Lucanthone 是 Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。

CAS No. :479-50-5

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PL08805-1 mL x 10 mM (in DMSO)		¥1165.00	请登录

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中文名称	Lucanthone
中文别名	硫坎酮;硫蒽酮;1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮
英文名称	Lucanthone
英文别名	Lucanthone;1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one;1-(2-Diaethylamino-aethylamino)-4-methyl-thioxanthen-9-on;1-(2-Diethylamino-ethylamino)-4-methylthiaxanthon,Lucanthon;1-(2-diethylamino-ethylamino)-4-methyl-thioxanthen-9-one;1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one;1-<2-Diaethylamino-aethylamino>-4-methyl-thioxanthenon-(9);Lycanthone;thioxanthone
Cas No.	479-50-5
分子式	C₂₀H₂₄N₂Os
分子量	340.48
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Lucanthone 是 Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。

产品详情

Lucanthone 是 Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。

生物活性

Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

性状

Solid

IC50 & Target[1][2]

APE-1

体外研究(In Vitro)

Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18.
[2]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.

溶解度数据	In Vitro: DMSO : 25 mg/mL (73.43 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Lucanthone

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