Nevirapine|129618-40-2|(奈韦拉平; BI-RG 587; NSC 641530; NVP)-陌孚医药/Medlife

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Nevirapine (Synonyms: 奈韦拉平; BI-RG 587; NSC 641530; NVP)

目录号: PL08831 纯度: ≥99%

CAS No. :129618-40-2

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中文名称	Nevirapine
中文别名	奈伟拉平;那韦拉平;萘维拉平;奈韦那平;萘韦拉平;11-环丙基-5,11-二氢-4-甲基-6H-二吡啶并[3,2-B:2',3'-E][1,4]二氮杂革-6-酮;奈夫拉平;(34-二甲基苯氧基)-乙酸肼;3,5,6三氯-4-羟基皮考啉酸;Nevirapine 奈韦拉平;奈韦拉平;奈韦拉平 EP标准品;奈韦拉平标准品;奈韦拉平-D5;奈韦拉平用于峰签定 EP标准品;无水奈韦拉平;无水奈韦拉平 USP标准品;11-环丙基-5,11-二羟基-4-甲基-6H-二吡啶并[3,2-b:2',3'-e][1,4]二氮杂唑-6-酮;奈韦拉平,那韦拉平;11-环丙基-5,11-二氢-4-甲基-6H-二吡啶并[3,2-b:2',3'-e][1,4]二氮杂卓-6-酮;那伟拉平;奈韦拉平(标准品);奈韦拉平 NEVIRAPINE
英文名称	Nevirapine
英文别名	11-Cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one;11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B',3'-E][1,4]DIAZEPIN-6-ONE;5-CYCLOPROPYL-9-METHYL-5,10-DIHYDRO-4,5,6,10-TETRAAZA-DIBENZO[A,D]CYCLOHEPTEN-11-ONE;6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-;NEVIRAPINE;VIRAMUNE;Novirapine*;Nevirapine(Nvp);NEVIRAPINE(SUBJECTTOPATENTFREE);Viramune (Nevirapine);BI-RG-587;Viramnune;5H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 5,11-dihydro-11-cyclopropyl-4-methyl-;11-Cyclopropyl-4-methyl-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine-6(5H)-one;4-Methyl-11-cyclopropyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one;5,11-Dihydro-11-cyclopropyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one;11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one;11-cyclopropyl-4-methyl-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one;11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-6：2’,3’-e][1,4]diazepin-6-one;11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one;11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2’,3’-][1,4] diazepin-6-one;BI-RG 587;Nevirapine Anhydrous;NSC 641530;NVP;11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one;D00435;Nevirapil;Nevarapine;AIDS005653;Nevirapine;Viramune
Cas No.	129618-40-2
分子式	C₁₅H₁₄N₄O
分子量	266.30
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Nevirapine (BI-RG 587) 是用于研究 HIV/AIDS 的 HIV-1 逆转录酶非核苷抑制剂，K_i 值为 270 μM。

生物活性

Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K i of 270 μM.

性状

Solid

IC50 & Target[1][2]

HIV-1

体外研究(In Vitro)

Nevirapine itself is an inhibitor of only CYP3A4 at concentrations that are well above those of therapeutic relevance (Ki=270 μM). Nevirapine has been used as a re-differentiation agent to treat cancers in several human cancer models. At all doses (100, 200, 350, 500 μM) tested, nevirapine significantly inhibits cell proliferation after 48 h treatment. At high dose (500 μM), nevirapine significantly increases the percentage of apoptotic cells compared with control. Nevirapine is a potent and selective inhibitor (IC50=10-100 nM) of the replication of a wide variety of HIV-1 strains in several cellular assays. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Nevirapine is available for use in combination with nucleoside HIV-1 reverse transcriptase inhibitors (e.g., zidovudine, didanosine, etc.). Nevirapine has received FDA approval for use in combination with HIV-1 protease inhibitors (e.g., saquinavir, ritonavir, indinavir, etc.). In humans, nevirapine is eliminated primarily in the urine as glucuronide conjugates of 2-, 3-, 8-, and 12-hydroxynevirapine. Nevirapine is completely absorbed in both sexes of mouse, rat, rabbit, monkey, and chimpanzee. Nevirapine is extensively metabolized in both sexes of all animal species studied. Nevirapine (9 mg/kg, 18 mg/kg and 36 mg/kg) shows significant reduction in ulcer severity score and ulcer index as compared to the control has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Erickson DA, et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitornevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95.
[2]. Dong JJ, et al. In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma. Mol Cell Endocrinol. 2013 May 6;370(1-2):113-8.

溶解度数据	In Vitro: DMSO : 14.29 mg/mL (53.66 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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