N-Desethyl amodiaquine-d5 (dihydrochloride)|1216894-33-5|(去乙基阿莫地喹盐酸盐-d-陌孚医药/Medlife

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N-Desethyl amodiaquine-d5 (dihydrochloride) (Synonyms: 去乙基阿莫地喹盐酸盐-d

目录号: PL08840

CAS No. :1216894-33-5

商品编号	规格	价格	会员价	是否有货	数量
PL08840-1mg	1mg	询价	询价
PL08840-10mg	10mg	询价	询价

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中文名称	N-Desethyl amodiaquine-d5 (dihydrochloride)
中文别名	N- 去甲基阿莫地喹-D5丁二盐酸盐;N-脱乙基阿莫地喹-D5二盐酸盐盐标准品;去乙基阿莫地喹-D5;[2H5]-N-去乙基阿莫地喹二盐酸盐;N-去乙基阿莫地喹-D5二氯
英文名称	N-Desethyl amodiaquine-d5 (dihydrochloride)
英文别名	N-Desethylamodiaquine-D5 dihydrochloride;4-[(7-chloroquinolin-4-yl)amino]-2-[(1,1,2,2,2-pentadeuterioethylamino)methyl]phenol,dihydrochloride;N-Desethylamodiaquine-D5 dihydrochloride solution;Desethylamodiaquine-D5 Dihydrochloride;Desethylamodiaquine-D5 Dihydrochloride 0.1 mg/ml in Methanol (as free base);4-[(7-chloroquinolin-4-yl)amino]-2-[(1,1,2,2,2-pentadeuterioethylamino)methyl]phenol;dihydrochloride;4-[(7-Chloroquinolin-4-yl)amino]-2-{[(~2~H_5_)ethylamino]methyl}phenol--hydrogen chloride (1/2);CID 45358919;N-Desethyl Amodiaquine D5 Di hydrochlorideQ: What is N-Desethyl Amodiaquine D5 Di hydrochloride Q: What is the CAS Number of N-Desethyl Amodiaquine D5 Di hydrochloride Q: What is the storage condition of N-Desethyl Amodiaquine D5 Di hydrochloride
Cas No.	1216894-33-5
分子式	C₁₈H₂₀Cl₃N₃O
分子量	405.76
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	N-Desethyl amodiaquine-d₅ (dihydrochloride) 是 N-Desethyl amodiaquine dihydrochloride 的氘代物。N-Desethyl amodiaquine dihydrochloride 是 Amodiaquine 的主要生物活性代谢产物。N-Desethyl amodiaquine dihydrochloride 是一种抗寄生虫剂，对菌株 V1/S 和 3D7 的 IC₅₀ 值分别为 97 nM 和 25 nM。
生物活性	N-Desethyl amodiaquine-d 5 (dihydrochloride) is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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