Nifurtimox|23256-30-6|(硝呋替莫)-陌孚医药/Medlife

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Nifurtimox (Synonyms: 硝呋替莫)

目录号: PL08856 纯度: ≥99%

CAS No. :23256-30-6

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中文名称	Nifurtimox
中文别名	硝呋替莫;Nifurtimox [4-氨基-3-甲基四氢-1,4-噻嗪-1,1-二氧化物];去甲环素;硝呋替莫-D4;硝呋莫司
英文名称	Nifurtimox
英文别名	4-Thiomorpholinamine,3-methyl-N-[(5-nitro-2-furanyl)methylene]-, 1,1-dioxide;Nifurtimox;(E)-N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitrofuran-2-yl)methanimine;3-methyl-4-[(5-nitrofurfurylidene)amino]thiomorpholine-1,1-dioxide;3-methyl-N-[(5-nitro-2-furanyl)methylene]-4-thiomorpholinamine-1,1-dioxide;4-(5-nitro-furfurylidene)amino-3-methylthiomorpholine 1,1-dioxide;4-Thiomorpholinamine,3-methyl-N-((5-nitro-2-furanyl)methylene)-,1,1-dioxide;BAY 2502;Bayer 2502;EINECS 245-531-0;Lampit;Nifurtimox [INN:BAN];Nifurtimoxum [INN-Latin];(±)-Nifurtimox;(RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide;Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide;3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide;4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide;3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide; 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide
Cas No.	23256-30-6
分子式	C₁₀H₁₃N₃O₅S
分子量	287.29
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Nifurtimox 是一种用于锥虫病 (Trypanosoma cruzi) 的抗虫剂。Nifurtimox 有潜力用于神经母细胞瘤细胞的研究。Nifurtimox 影响乳酸脱氢酶 (LDH) 活性。

生物活性

Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

性状

Solid

IC50 & Target[1][2]

Trypanosoma cruzi
Lactate dehydrogenase (LDH)

体外研究(In Vitro)

Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH). To differentiate if this effect is a result of a reduced LDH activity or a shift in pyruvate metabolism due to activation of PDH, the enzyme activity of LDH is determined after 4 h treatment with 50 μg/mL Nifurtimox. Compared to the untreated control, the LDH activity is significantly reduced for LA-N-1 (P=0.005), IMR-32 (P=0.009), LS (P=0.0035) and SK-N-SH (P=0.0065). Nifurtimox reduces cell viability and induces cell cycle arrest and apoptosis in neuroblastoma cells. To characterize the cytotoxic impacts of Nifurtimox on neuroblastoma, 4 cell lines are subjected to several experiments. Cell viability is reduced for all 4 neuroblastoma cell lines after 24 h incubation with 50 μg/mL to an average of 66%, 63%, 62% and 75% (LA-N-1, IMR-32 LS and SK-N-SH, respectively). The reduction is significant compared to the

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Cabanillas Stanchi KM, et al. Nifurtimox reduces N-Myc expression and aerobic glycolysis in neuroblastoma. Cancer Biol Ther. 2015;16(9):1353-63.

溶解度数据	In Vitro: DMSO : 150 mg/mL (522.10 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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