Fluralaner|864731-61-3|(A1443; AH252723)-陌孚医药/Medlife

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Fluralaner (Synonyms: A1443; AH252723)

目录号: PL08824 纯度: ≥99%

Fluralaner (INN)是一种全身性杀虫剂和杀螨剂，通过有效阻断 GABA 和 L-glutamate 氯化物通道。

CAS No. :864731-61-3

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中文名称	Fluralaner
中文别名	氟雷拉纳;Fluralaner
英文名称	Fluralaner
英文别名	4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide;Fluralaner;A1443;AH252723
Cas No.	864731-61-3
分子式	C₂₂H₁₇Cl₂F₆N₃O₃
分子量	556.29
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Fluralaner (INN)是一种全身性杀虫剂和杀螨剂，通过有效阻断 GABA 和 L-glutamate 氯化物通道。
生物活性	Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
性状	Solid
IC50 & Target[1][2]	Mite
体外研究(In Vitro)	Fluralaner potently inhibits flea reproduction capacity in vitro . Oviposition ceases completely at concentrations as low as 25.0 ng/mL. While no ovicidal effect is observed, fluralaner exerts a larvicidal effect at exceptionally low concentrations (6.25 ng/mL). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In the simulated flea-infested home environment, flea-control efficacy on fluralaner-treated dogs is >99% at every time point measured for 12 weeks. No adverse events are observed in fluralaner-treated dogs. Fluralaner completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275. [2]. Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.

溶解度数据	In Vitro: DMSO : 200 mg/mL (359.52 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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