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产品总数：61554
| 中文名称 |
Robenidine hydrochloride
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|---|---|
| 中文别名 |
盐酸氯苯胍;1,3-双(对氯苄叉氨基)胍盐酸盐;罗贝胍;氯苯胍;1,3-双(双氯苯叉氨基)胍盐酸盐;2-(对氨基苯磺酰氨基)-4,6-二甲基嘧啶;1,3-双-(氯亚苯基氨基)胍盐酸盐;罗本尼丁(ROBEAIDINE)百乐君;氯苯胍盐酸盐;1-BOC-6-甲基-1,4-二氮杂环庚烷;盐酸氯苯胍 标准品;双氯苄氨胍盐酸盐;1,3-双[(4-氯苯亚甲基)氨基]胍 单盐酸盐;盐酸氯苯胍原药粉生产厂家行情价格
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| 英文名称 |
Robenidine hydrochloride
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| 英文别名 |
cycostat;1,3-BIS[(4-CHLOROBENZYLIDENE)AMINO]GUANIDINE MONOHYDROCHLORIDE;ROBENIDINE HCL;1,3-bis((p-chlorobenzylidene)amino)guanidinehydrochloride;1,3-bis((p-chlorobenzylidene)amino)-guanidinmonohydrochloride;bis((4-chlorophenyl)methylene)-carbonimidicdihydrazidmonohydrochloride;Robenzidene, Cycostat, Robenz;ROBENDINE HCL;Carbonimidic dihydrazide, bis(4-chlorophenyl)methylene-, monohydrochloride;khimroside;Robenidinhydrochlorid;1,3-bis((p-chlorobenzylidene)amino)-guanidin;1,3-bis((p-chlorobenzylidene)amino)guanidine;bis((4-chlorophenyl)methylene)-carbonimidic dihydrazid;chimcoccide;khimcoccid;khimkoktsid;khimkoktside;Celecoxib;Robenidine Hydrochlo;Robenidine hydrochloride;Robenidine HCl, Vetranal;盐酸氯苯胍原药粉生产厂家行情价格
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| Cas No. |
25875-50-7
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| 分子式 |
C15H13Cl2N5.HCl
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| 分子量 |
370.66
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 详情描述 |
Robenidine hydrochloride 是一种抗球虫药, 对 MRSA 和 VRE 也有抑制活性，其 MIC50 值分别为 8.1 和 4.7 μM。 |
| 产品详情 |
Robenidine hydrochloride 是一种抗球虫药, 对 MRSA 和 VRE 也有抑制活性，其 MIC50 值分别为 8.1 和 4.7 μM。
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|---|---|
| 生物活性 |
Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC 50 s of 8.1 and 4.7 μM, respectively.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Coccidia
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| 体外研究(In Vitro) |
Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t 1/2z ), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λ z ) and total body clearance (CL z ) obviously increased in rabbits pretreated with Robenidine. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 参考文献 |
[1]. Abraham RJ, et al. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10;59(5):2126-38.[2]. Liu C, et al. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64(1):73-9.
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| 溶解度数据 |
In Vitro: DMSO : 6.25 mg/mL (16.86 mM; Need ultrasonic)H2O : 1 mg/mL (2.70 mM; ultrasonic and warming and heat to 80°C)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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