LY487379 是一种选择性人 mGluR2 正变构调节剂 (PAM)。LY487379 增强谷氨酸刺激[³⁵S]GTPγS 与 EC₅₀ 值分别为 1.7 μM 和 >10 μM 的 mGlu2 和 mGlu3 受体的结合。LY487379 可促进大鼠认知灵活性，促进行为抑制。LY487379 可用于精神分裂症研究。

LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [S]GTPγS binding with EC 50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research.

Solid

LY487379 (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage.
LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats.
has not independently confirmed the accuracy of these methods. They are for reference only.

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Powder -20°C 3 years；In solvent -80°C 6 months

[1]. Nikiforuk A, et al. Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J Pharmacol Exp Ther. 2010;335(3):665-673.
[2]. Schaffhauser H, et al. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol. 2003;64(4):798-810.

In Vitro: DMSO : 100 mg/mL (221.02 mM; Need ultrasonic)配制储备液