Pomaglumetad methionil hydrochloride|635318-26-2|(LY2140023 hydrochloride)-陌孚医药/Medlife

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Pomaglumetad methionil hydrochloride (Synonyms: LY2140023 hydrochloride)

目录号: PL07119 纯度: ≥98%

CAS No. :635318-26-2

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PL07119-50mg	50mg	¥61880.00	请登录
PL07119-100mg	100mg	¥94025.00	请登录
PL07119-200mg	200mg	询价	询价
PL07119-500mg	500mg	询价	询价

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中文名称	Pomaglumetad methionil hydrochloride
中文别名	LY2140023 hydrochloride
英文名称	Pomaglumetad methionil hydrochloride
英文别名	LY2140023 hydrochloride;Pomaglumetad methionil hydrochloride;Pomaglumetad methionil HCl;(1R,4S,5S,6S)-4-(L-Methionylamino)-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid 2,2-dioxide hydrochloride
Cas No.	635318-26-2
分子式	C₁₂H₁₉ClN₂O₇S₂
分子量	402.87
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) 是一种选择性 mGlu2/3 受体激动剂 LY404039 的蛋氨酸前药，具有口服活性。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。

生物活性

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.

性状

Solid

IC50 & Target[1][2]

mGluR2 mGluR3

体外研究(In Vitro)

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM.
LY2140023 is active against [C]Gly-Sar with an IC50 value of 0.018 mM. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) . has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

ClinicalTrial

参考文献

[1]. Lowe S, et al. Effects of a novel mGlu_?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70.
[2]. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144.

溶解度数据	In Vitro: DMSO : 25 mg/mL (62.05 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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