PTD-p65-P1 Peptide TFA 是一种有效的选择性核转录因子 NF-κB 抑制剂，来源于 NF-κB 氨基酸残基 271-282 的 p65 亚单位，可选择性抑制各种炎症刺激诱导的 NF-κB 激活，下调 NF-κB 介导的基因表达，并上调细胞凋亡(apoptosis)。

PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

Solid

NF-kappaB

PTD-p65-P1 Peptide TFA (10-150 μM; 0-60 min; KBM-5 cells) inhibits TNF-induced NF-κB activation in a dose-dependent manner and suppresses TNF-induced NF-κB activation by 25% at 100 μM and completely at 150 μM.
PTD-p65-P1 Peptide TFA (150 μM; 0-60 min; KBM-5 cells) inhibits cytoplasmic p65 phosphorylation and nuclear translocation.
PTD-p65-P1 Peptide TFA (100 μM; 16 h; KBM-5 cells) potentiates the TNF-induced apoptosis from 4 to 45%.
PTD-p65-P1 Peptide TFA (150 μM; A 293 cells) inhibits NF-κB-dependent reporter gene expression induced by TNF.
PTD-p65-P1 Peptide TFA (150 μM; 12-24 h; SP-53 cells ) inhibits the cell proliferation. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

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[1]. Takada Y, et, al. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 20
[2]. Shishodia S, et, al. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005 Sep 1;70(5):700-13.