Bax inhibitor peptide V5|579492-81-2|(BIP-V5; BAX Inhibiting Peptide V5)-陌孚医药/Medlife

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Bax inhibitor peptide V5 (Synonyms: BIP-V5; BAX Inhibiting Peptide V5)

目录号: PL05753 纯度: ≥98%

CAS No. :579492-81-2

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PL05753-100mg	100mg	询价	询价
PL05753-200mg	200mg	询价	询价

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中文名称	Bax inhibitor peptide V5
中文别名	BAX INHIBITING PEPTIDE V5 (BIP-V5)
英文名称	Bax inhibitor peptide V5
英文别名	BAX INHIBITING PEPTIDE V5 (BIP-V5);BAX Inhibiting Peptide V5;Bax inhibitor peptide V5;BIP-V5;Val-Pro-Met-Leu-Lys;(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid;BAX Inhibiting Peptide V5; BIP-V5
Cas No.	579492-81-2
分子式	C₂₇H₅₀N₆O₆S
分子量	586.79
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Bax inhibitor peptide V5 (BIP-V5) 是一种 Bax 诱导凋亡的抑制剂，主要用于癌症研究。
生物活性	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
性状	Solid
IC50 & Target[1][2]	Bax
体外研究(In Vitro)	Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	VPMLK
参考文献	[1]. Jo MJ, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65. [2]. Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (170.42 mM)H₂O : 100 mg/mL (170.42 mM; Need ultrasonic)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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