Hematoporphyrin dihydrochloride|17696-69-4|(血卟啉二盐酸盐; Hematoporphyrin IX dihydrochloride)-陌孚医药/Medlife

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Hematoporphyrin dihydrochloride (Synonyms: 血卟啉二盐酸盐; Hematoporphyrin IX dihydrochloride)

目录号: PL05404 纯度: ≥98%

CAS No. :17696-69-4

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PL05404-200mg	200mg	询价	询价
PL05404-500mg	500mg	询价	询价

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中文名称	Hematoporphyrin dihydrochloride
中文别名	血卟啉二.盐酸盐;血卟啉二盐酸盐;(2R,3R)-1-(二甲基氨基)-3-(3-甲氧基苯基)-2-甲基-3-戊醇;HAEMATOPORPHYRIN 二盐酸化物(RG);血卟啉;血卟啉IX二氯化氢;血卟啉二盐酸化物;血卟啉盐酸盐;盐酸血紫质;盐酸血紫素;血紫素盐酸盐;二盐酸血紫素;卤代卟啉盐酸盐;一水合二盐酸血卟啉;血卟啉盐酸盐(一水)
英文名称	Hematoporphyrin dihydrochloride
英文别名	Haematoporphyrin dihydrochloride;Hematoporphyrin dihydrochloride;Hematoporphyrin IX dihydrochloride;Haematopophyrin dihydrochloride;Hematoporphyrin hydrochloride;Hematoporphyrin (dihydrochloride);Hematoporphyrin IX dihydrochloride,8,13-Bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid dihydrochloride;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid hydrochloride;ematoporfirina;Hemaloporphyrin;HematoporphyrineDihcl;HAEMATOPORPHYRINDICHLORIDE;HAEMATOPORPHYRIN Dihydrochloride(RG);8,13-Bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid dihydrochloride;Apiabasilon;Vitamorell;Ematoporfirina [Italian];Hematoporphyrin dichydrochloride;Acido 1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionico dicloridrato
Cas No.	17696-69-4
分子式	C₃₄H₄₀Cl₂N₄O₆
分子量	671.61
包装储存	4°C, sealed storage, away from moistur 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

产品详情

Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一种光敏剂，是血红素结合蛋白亲和色谱底物。当暴露于红光下时，Hematoporphyrin dihydrochloride 可以诱导 U87 胶质瘤细胞凋亡，并降低体内肿瘤的生长。

生物活性

Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light.

性状

Solid

体外研究(In Vitro)

Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC50s of 85 and 166 nM, respectively.
Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.
Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

ClinicalTrial

参考文献

[1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.
[2]. Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin?induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (93.06 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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