Flubendazole-d3|1173021-08-3|-陌孚医药/Medlife

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Flubendazole-d3

目录号: PL05316

CAS No. :1173021-08-3

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中文名称	Flubendazole-d3
中文别名	氟苯咪唑-D3氘代内标;FlubendazoleD3 标准品;WITEGABI027芬苯哒唑-D3标准品;芬苯哒唑-D3标准品;氟苯哒唑-D3;氟苯达唑-d3(甲基-d3);氟苯咪唑-D3;氟苯咪唑-D3 标准品;甲基-d3 [5-(4-氟苯甲酰)-1H-苯并咪唑-2-基]氨基甲酸
英文名称	Flubendazole-d3
英文别名	Flubendazole-d3?(methyl-d3);Flubendazole-d3;trideuteriomethyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
Cas No.	1173021-08-3
分子式	C₁₆H₁₂N₃O₃F
分子量	313.28
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Flubendazole-d₃ 是 Flubendazole 的氘代物。Flubendazole 是一种安全有效的驱虫药物，广泛应用于人类、啮齿动物和反刍动物的驱虫。Flubendazole 通过抑制微管功能等机制发挥抗癌作用。Flubendazole 诱导 p53 介导的细胞凋亡，抑制 G2/M 细胞周期。
生物活性	Flubendazole-d 3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic drug, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Michaelis M, et al. Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen. Sci Rep. 2015 Feb 3;5:8202. [3]. Zhou X, et al. Flub

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