Lidocaine-d10 (hydrochloride)|1189959-13-4|(盐酸利多卡因 d-陌孚医药/Medlife

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Lidocaine-d10 (hydrochloride) (Synonyms: 盐酸利多卡因 d

目录号: PL05280

CAS No. :1189959-13-4

商品编号	规格	价格	会员价	是否有货	数量
PL05280-5mg	5mg	询价	询价
PL05280-50mg	50mg	询价	询价

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中文名称	Lidocaine-d10 (hydrochloride)
中文别名	盐酸利多卡因-D10氘代内标;盐酸利多卡因-D10;盐酸利多卡因 d10 (盐酸盐)
英文名称	Lidocaine-d10 (hydrochloride)
英文别名	Lidocaine-d10 HCl (N,N-diethyl-d10);Lidocaine-d10 Hydrochloride;N-(2,6-dimethylphenyl)-2-[1,1,2,2,2-pentadeuterioethyl(2,2,2-trideuterioethyl)amino]acetamide,hydrochloride;Lidocaine-d10 (hydrochloride)
Cas No.	1189959-13-4
分子式	C₁₄H₂₃ClN₂O
分子量	278.85
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Lidocaine-d₁₀ (hydrochloride) 是 Lidocaine hydrochloride 的氘代物。Lidocaine (Lignocaine) hydrochloride 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine hydrochloride 是一种酰胺衍生物，具有研究室性心律失常的潜力。
生物活性	Lidocaine-d 10 (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia[2].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaines use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11. [3]. Sui H,

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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