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| 中文名称 |
L-Asparaginase
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|---|---|
| 中文别名 |
L-天门冬酰胺酶
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| 英文名称 |
L-Asparaginase
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| 英文别名 |
L-Asparaginase;Acrylaway L;Asparaginase 2;Asparaginase medac;Asparaginases;Colaspase;Crasnitin;Crasnitins;E.C. 3.5.1.1;EC 3.5.1.1;Elspar;JZP 458;Kidrolase;Kidrolases;L-Asnase;L-Asparaginases;L-Asparagine amidohydrolase;L-Asparagine amidohydrolases;Leunase;Leunases;MK 965;MeSH ID: D001215;NSC 109229;Oncospar;PreventASe;Preventase M;Spectrila;α-Asparaginase;α-Asparaginases
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| Cas No. |
9015-68-3
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| 包装储存 |
Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
L-Asparaginase (L-ASNase) 是一种脱酰胺酶，催化 L-天冬酰胺和 L-谷氨酰胺水解，可用于急性淋巴细胞白血病的研究。L-Asparaginase 从血浆中去除 L-天冬酰胺会导致 RNA 和 DNA 合成抑制，随后引起细胞凋亡。
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|---|---|
| 生物活性 |
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis.
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| 性状 |
Solid
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| 体外研究(In Vitro) |
L-Asparaginase has a cytotoxic effect on AML blasts and LSC subpopulations.L-Asparaginase is effective on both CD34CD38 and CD34CD38 LSC fractions, MSC and monocytes/macrophages partially counteracted the effect. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
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| ClinicalTrial |
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| 参考文献 |
[1]. Ilaria M Michelozzi, et al. Acute myeloid leukaemia niche regulates response to L-asparaginase. Br J Haematol. 2019 Aug;186(3):420-430. doi: 10.1111/bjh.15920.
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| 溶解度数据 |
In Vitro: 0.1 M HCL : 50 mg/mL (ultrasonic and adjust pH to 3 with HCl)H2O : 1 mg/mL (ultrasonic and warming and heat to 50°C)In Vivo:
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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