Dynorphin A|80448-90-4|(强啡肽A)-陌孚医药/Medlife

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Dynorphin A (Synonyms: 强啡肽A)

目录号: PL05836 纯度: ≥98%

CAS No. :80448-90-4

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中文名称	Dynorphin A
中文别名	强啡肽A(猪);强啡肽A;强啡肽 A (猪)
英文名称	Dynorphin A
英文别名	Dynorphin A (swine);DYNORPHIN A;Dynorphin A NEW;Dynorphin A, Prodynorphin (207-223) (human), Prodynorphin (209-225) (porcine);DYNORPHIN A AMIDE;DYNORPHIN A PORCINE;Dynorphin acetate;Prodynorphin (209-225),porcine;YGGFLRRIRPKLKWDNQ;Dynorphin-(1-17)
Cas No.	80448-90-4
分子式	C₉₉H₁₅₅N₃₁O₂₃
分子量	2147.48
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	Dynorphin A 是一种内源性阿片肽，参与中枢神经系统 (CNS) 的抑制性神经传递。Dynorphin A 是一种高效的 kappa 阿片受体 (KOR) 激动剂，也是其他阿片受体的激动剂，如 mu (MOR) 和 delta (DOR)。Dynorphin A 可诱导神经元死亡，可用于神经系统疾病的相关研究。
生物活性	Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite Caspase 3
体外研究(In Vitro)	Dynorphin A (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death. dynorphin A (33 μM, 4 h) elevates [Ca]i and causes a significant loss of neurons. dynorphin A (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe. has not independently confirmed the accuracy of these methods. They are for reference only.Cell
体内研究(In Vivo)	Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats. Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	YGGFLRRIRPKLKWDNQ
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
参考文献	[1]. Zhang, et al.Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family. J Pharmacol Exp Ther. 1998 Jul;286(1):136-41. [2]. Aruna Sharma, et al. Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair. Int Rev Neurobiol. 2012;102:23-45. [3]. I. N. S

溶解度数据	In Vitro: DMSO : 120 mg/mL (55.88 mM; Need ultrasonic)配制储备液

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