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Clofilium tosylate

目录号: PL05023 纯度: ≥98%

Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂，作用于人早幼粒细胞白血病 (HL-60) 细胞，激活 caspase-3 而诱导凋亡。具有抗心律失常作用。

CAS No. :92953-10-1

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中文名称	Clofilium tosylate
中文别名	对甲苯磺酸氯非铵;氯非铵对甲苯磺酸盐;氯非铵甲苯磺酸盐
英文名称	Clofilium tosylate
英文别名	Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl-, salt with 4-methylbenzenesulfonicacid (1:1);4-(4-chlorophenyl)butyl-diethyl-heptylazanium,4-methylbenzenesulfonate;CLOFILIUM TOSYLATE;4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate;Prestwick_682;N-(4-(4-Chlorophenyl)butyl)-N,N-diethylheptan-1-aminium 4-methylbenzenesulfonate;13ZVF1051K;DSSTox_RID_80994;DSSTox_CID_25601;DSSTox_GSID_45601;MLS002154263;4-Chloro-N,N-Diethyl-N-Heptyl-Benzenebutanaminiusaltwith4-Methylbenzenes;clofilium tosylateclofilium tosylate;SMR001233522;4-Chloro-N,;Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl-, salt with 4-methylbenzenesulfonic acid (1:1) (9CI);Clofilium tosylate
Cas No.	92953-10-1
分子式	C₂₈H₄₄ClNO₃S
分子量	510.17
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂，作用于人早幼粒细胞白血病 (HL-60) 细胞，激活 caspase-3 而诱导凋亡。具有抗心律失常作用。
生物活性	Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent.
性状	Solid
IC50 & Target[1][2]	Potassium channel
体外研究(In Vitro)	HL-60 cells treated with Clofilium (0-20 μM; 24, 48, and 72 hours) lead to suppression of viability and proliferation in both time and concentration-dependent manners. Cell viability decreases significantly in HL-60 cells treated with 2.5 μM to 10 μM of Clofilium. Clofilium (10 μM, 12 hours) induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP at 2 h after exposure to 10 mM Clofilium. However, there is no significant change in expression of Bcl-2 and Bax proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Choi BY, et al. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 1999 Dec 1;147(1-2):85-93.

溶解度数据	In Vitro: DMSO : 100 mg/mL (196.01 mM; Need ultrasonic)H₂O : 1.59 mg/mL (3.12 mM; ultrasonic and warming and heat to 60°C)配制储备液

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Clofilium tosylate

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