SIBA (5'-Isobutylthioadenosine) 是一种 Transmethylation 抑制剂 (SAH (HY-19528) 类似物)，具有强大的抗增殖活性。SIBA 通过阻断甲基化，特别是阻断病毒 mRNA 的5' 端加帽，可逆地抑制 HSV-1 的产生。SIBA 还能抑制肿瘤细胞系的体外生长和体内转移扩散。SIBA 可用于癌症，HSV-1 感染和抗疟疾的研究。

SIBA (5-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5 end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies.

Solid

Plasmodium HSV-1

SIBA (0.5 mM; 24-96 h) shows strong anti-proliferative activity against 3LL and RMS-J1 tumour cells.
SIBA (1 mM; 12, 24 h) reversibly inhibits HSV production in HEp2 cells (infected by HSV-1).
SIBA inhibits protein synthesis by 98% after 10 h infection of HEp2 cells (infected by HSV-1).
SIBA (1 mM; 8.5 h) inhibits protein synthesis and RNA methylation in HEp2 cells (infected by HSV-1).
SIBA (0.5, 1.0 mM; 24, 48 h) inhibits the conversion of putrescine into spermidine and/or spermine and that this inhibition is a reversible one (interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase). has not independently confirmed the accuracy of these methods. They are for reference only.

SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo.
SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16.
[2]. B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5 S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7.

In Vitro: DMSO : ≥ 100 mg/mL (294.63 mM)配制储备液