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Theaflavin 3,3'-digallate

(Synonyms: 茶黄素-3,3'-双没食子酸; TF-3; ZP10)

目录号: PC58313 纯度: ≥99%

Theaflavin 3,3'-digallate (TF-3) 是有效的寨卡病毒 (ZIKV) 蛋白酶抑制剂，IC50 为 2.3 μM。Theaflavin 3,3'-digallate 直接与 ZIKVpro 结合 (Kd=8.86 µM) 并抑制 ZIKV 复制。

CAS No. :30462-35-2

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中文名称	Theaflavin 3,3'-digallate
中文别名	3,3’-二没食子酸酯茶黄素;3,3'-二没食子酸酯茶黄素;茶黄素3,3' - 双没食子酸酯;茶黄素3,3' -没食子酸酯;茶黄素-3,3'-双没食子酸酯;茶黄素-3,3'-双没食子酸
英文名称	Theaflavin 3,3'-digallate
英文别名	8-Gingerol;Theaflavin 3;Theaflavin 3,3'-di-O-gallate;3,4,5-Trihydroxybenzoic acid (3,4,6-trihydroxy-5-oxo-5H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl] ester;[(2R,3R)-2-[1-[(2R,3R)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-2-yl]-3,4,5-trihydroxy-6-oxobenzo[7]annulen-8-yl]-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxy;Theaflavin 3,3′-digallate;THEAFLAVIN 3,3'-DIGALLATE;THEAFLAVINE-3,3'-DIGALLATE;theaflavin 3,3'-gallate;theaflavin 3,3'-O-digallate;Theaflavin-3,3'-digallate;theaflavin-3,3'-di-O-gallate
Cas No.	30462-35-2
分子式	C₄₃H₃₂O₂₀
分子量	868.70
包装储存	-20°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；
详情描述	Theaflavin 3,3'-digallate (TF-3) 是有效的寨卡病毒 (ZIKV) 蛋白酶抑制剂，IC50 为 2.3 μM。Theaflavin 3,3'-digallate 直接与 ZIKVpro 结合 (Kd=8.86 µM) 并抑制 ZIKV 复制。Theaflavin 3,3'-digallate 抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1 病毒活性。Theaflavin 3,3'-digallate 是红茶中的典型色素，一种有效的抗肿瘤剂。

生物活性

Theaflavin 3,3-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of2.3 μM. Theaflavin 3,3-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1. Theaflavin 3,3-digallate, the typical pigment in black tea, is a potent antitumor agent.

性状

Solid

IC50 & Target[1][2]

HSV
HIV-1

体外研究(In Vitro)

Theaflavin 3,3-digallate (TF-3; 6.25, 12.5, 25 μM; 24 hours) markedly reduces viral RNA copy numbers and NS3, U87 MG protein expression in a dose-dependent manner.
Theaflavin 3,3-digallate inhibits dose-dependently ZIKV replication in Vero E6 cells (EC50=7.65 μM). Theaflavin 3,3-digallate has minor cytotoxicity up to 40 μM in Vero E6 cells. Theaflavin 3,3-digallate can inhibit the post-entry events of the ZIKV replication cycle from gene transcription and translation levels.
Theaflavin 3,3-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic

运输条件

Room temperature or refrigerated transport.

储存方式

-20°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

ClinicalTrial

结构分类

Flavonoids
Flavan

来源

Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(115.11 mM;Need ultrasonic) 配制储存液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Theaflavin 3,3'-digallate

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