Cytarabine.|147-94-4|(阿糖胞苷; Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C)-陌孚医药/Medlife

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Cytarabine. (Synonyms: 阿糖胞苷; Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C)

目录号: PC61644 纯度: 10mM*1mL in DMSO

CAS No. :147-94-4

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中文名称	Cytarabine.
中文别名	阿糖胞苷;1-beta-D-阿拉伯呋喃糖基-4-氨基-2(1H)-嘧啶酮;胞嘧啶-β-D-呋喃阿拉伯糖苷;阿拉伯糖胞嘧啶;胞嘧啶阿拉伯糖苷;阿拉伯呋喃糖基胞嘧啶;阿拉伯糖基胞嘧啶;1-BETA-D-阿拉伯呋喃糖基-4-氨基-2(1H)-嘧啶;海綿胞嘧啶;胞嘧啶核苷(胞苷);Cutosine β-D- 阿糖胞苷;Cytarabine 阿糖胞苷;阿糖胞苷 EP标准品;阿糖胞苷 USP标准品;阿糖胞苷-13C-15N2;阿糖胞苷-13C3;阿糖胞苷标准品;阿糖胞嘧啶;阿糖胞嘧啶（阿糖胞苷）;阿扎胞苷;胞嘧啶 β-D-阿拉伯呋喃糖苷;羟基喜树碱;(β-D-阿拉伯呋喃糖基)胞嘧啶;1-β-D-阿拉伯呋喃糖基-4-氨基-2(1H)-嘧啶酮;阿哌沙班;阿糖呋喃胞嘧啶;胞嘧啶-1-Β-D(+)-阿拉伯呋喃酐;胞嘧啶β-D-呋喃阿拉伯糖苷;胞嘧啶-β-D-呋喃阿拉伯糖苷,1-β-D-阿拉伯呋喃糖基-4-氨基-2(1H)-嘧啶酮;4-氨基-1-β-D-阿拉伯呋喃糖基-2(1H)-嘧啶酮;阿糖胞苷(标准品);胞嘧啶 β-D-呋喃阿拉伯糖苷;阿糖胞苷, 97+%
英文名称	Cytarabine
英文别名	4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;1-B-D-ARABINOFURANOSYL CYTOSIN;1-[BETA-D-ARABINOFURANOSYL]CYTOSINE;2'-ARACYTIDINE;4-AMINO-1-BETA-D-ARABINOFURANOSYL-2(1H)-PYRIMIDINONE;ARABINOCYRIDINE;ARABINOFURANOSYLCYTOSINE;ARABINOSYLCYTOSINE;CYTARABINE;CYTOSINE-1-BETA-D(+)-ARABINOFURANOSIDE;CYTOSINE ARABINOSIDE;CYTOSINE BETA-D-ARABINOFURANOSIDE;1-arabinofuranosylcytosine;1-beta-arabinofuranosylcytosine;1-beta-d-arabinofuranosyl-4-amino-2(1h)pyrimidinone;1-beta-d-arabinofuranosyl-cytosin;1-beta-d-arabinosyl-cytosin;1-beta-d-arabinosylcytosine;Cytosine β-D-arabinofuranoside;1-β-D-Arabinofuranosylcytosine;Cytarabine hydrochloride;(β-D-Arabinofuranosyl)cytosine;4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone;Ara-C;Arabinocytidine;udicil;Iretin;arafcyt;cytosar;Citozar;Ara-cell;arabitin;aracytin;Cytarabin;Tarabine;Alexan;Cytosar-U;1-beta-D-Arabinofuranosylcytosine;Cytarabina;Depocyt;DepoCyte;Citarabina;Cytarabinum;Aracytine;Aracytidine;Cytosinearabinoside;Cytarabinoside;Cytosine-beta-D-arabinofuranoside;Cytonal;Cytosine arabinofuranoside;beta-D-Arabinosylcytosine;Depocyt (liposomal);Cytarabinum [INN-
Cas No.	147-94-4
分子式	C₉H₁₃N₃O₅
分子量	243.22
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite
HSV-1

体外研究(In Vitro)

Cytarabine is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM. Cytarabine apparently induces apoptosis of rat sympathetic neurons at 10 μM, of which 100 μM shows the highest toxicity and kills over 80% of the neurons by 84 hours, involving the release of mitochondrial cytochrome-c and the activation of caspase-3, and the toxicity can be attenuated by p53 knockdown and delayed by bax deletion.Medlife has not independently confirmed the accuracy of these methods. They are for refer

体内研究(In Vivo)

Cytarabine (250 mg/kg) also causes placental growth retardation and increases placental trophoblastic cells apoptosis in the placental labyrinth zone of the pregnant Slc:Wistar rats, which increases from 3 hour after the treatment and peaks at 6 hour before returning to control levels at 48 hour, with remarkably enhanced p53 protein, p53 trancriptional target genes such as p21, cyclinG1 and fas and caspase-3 activity. Cytarabine is highly effective against acute leukaemias, which causes theCytarabine teristic G1/S blockage and synchronization, and increases the survival time for leukaemic Brown Norway rats in a weak dose-related fashion indicating that the use of higher dosages of Cytarabine does not contribute to its antileukaemic effectiveness in man.Medlife has not independently confirmed the accuracy of these methods. Th

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Others

来源

Xerocomus nigromaculatus

溶解度数据	体外研究: H₂O : 48 mg/mL(197.35 mM;Need ultrasonic) DMSO : 17.3 mg/mL(71.13 mM;Need ultrasonic and warming) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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