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2-Deoxy-D-glucose.

(Synonyms: 2-脱氧-D-葡萄糖; 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose)

目录号: PC63816 纯度: ≥99.0%

2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。

CAS No. :154-17-6

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中文名称	2-Deoxy-D-glucose.
中文别名	2-脱氧葡萄糖;2-脱氧-D-葡萄糖;2-去氧-D-葡萄糖;D-2-脱氧葡萄糖;2-Deoxy-D-glucose 2-脱氧-D-葡萄糖;2-脫氧-D-葡萄糖;2-脱氧-D葡萄糖;2-脱氧葡萄糖原药;D-2-脱氧葡萄糖 USP标准品;夫西地酸;脱氧葡萄糖;2-去氧-D-葡糖;2-去氧-D-葡萄糖,D-2-脱氧葡萄糖;2-脱氧-D-葡糖;D-2-脱氧葡萄;抗感染药;玫瑰红银试剂;去氧葡萄糖;D-2-脱氧葡萄糖 1G;2-去氧-D-葡萄糖,98%
英文名称	2-Deoxy-D-glucose
英文别名	2-Deoxy-D-Glucose;2-deoxy-D-glucose, mixture of anomers;2-deoxy-D-glucose grade iii;2-deoxy-D-glucose grade ii;2-Deoxy-D-Arabino;2-DEOXY-D-ARABINOHEXOSE;2-Deoxy-D-glucose (2-DG,NSC 15193,Ba 2758);DEOXY-D-GLUCOSE, 2-(RG);2-deoxy-d-arabino-hexos;2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose;p-DiMethylaMinobenzalrhodanine;2-Deoxyglucose;2-dg;ba2758;D-2dGlc;nsc15193;deoxyglucose;2-deoxy-glucos;D-2-GLUCODESOSE;d-2-deoxyglucose;2-deoxy-d-glucos;2-Deoxy-D-mannose;D-Arabino-hexose, 2-deoxy-;arabino-Hexose, 2-deoxy-;D-Glucose, 2-deoxy-;9G2MP84A8W;(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal;2 Deoxyglucose;2 Deoxy D glucose;2 Desoxy D glucose;D-arabino-2-desoxyhexose;deoxy-d-glucose, 2-;2-DEOXYLGLUCOSE;2-INNo-D-AEIIC;KSC175S5P;Jsp003004;VRYA
Cas No.	154-17-6
分子式	C₆H₁₂O₅
分子量	164.16
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。

生物活性	2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
性状	Solid
IC50 & Target[1][2]	HSV-1

体外研究(In Vitro)

2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells.Medlife has not independently confirmed the accuracy of these methods. They a

体内研究(In Vivo)

2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Saccharides
Monos

溶解度数据	体外研究: H₂O : ≥ 24 mg/mL(146.20 mM) *≥ means soluble, but saturation unknown. 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

2-Deoxy-D-glucose.

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