Omaciclovir|124265-89-0|(H2G)-陌孚医药/Medlife

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Omaciclovir (Synonyms: H2G)

目录号: PL02288 纯度: ≥99%

CAS No. :124265-89-0

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中文名称	Omaciclovir
英文名称	Omaciclovir
英文别名	6H-Purin-6-one,2-amino-1,9-dihydro-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-;(R)-9-(2-Hydroxymethyl-4-hydroxybutyl)guanine;2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one;OMACICLOVIR;2-HMHBG;C9H909GLI3;Omaciclovir [USAN:INN];H 2G;Omaciclovir (USAN/INN);(?)-2HM-HBG;D05250;(r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine;9-((R)-4-Hydroxy-2-(hydroxymethyl)butyl)guanine;Q27275359;2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-1H-purin-6-one;(R)-2-Amino-9-(4-hydroxy-2-(hydr
Cas No.	124265-89-0
分子式	C₁₀H₁₅N₅O₃
分子量	253.26
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Omaciclovir (H2G) 是一种有效的选择性疱疹病毒 herpesvirus 复制抑制剂。Omaciclovir 是一种核苷类似物。
生物活性	Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity.
性状	Solid
体外研究(In Vitro)	Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys. Omaciclovir shows antiviral activities against different human herpesviruses with EC50s of 0.72?±?0.1, 0.62?±?0.2, 0.015?±?0.004, 0.048?±?0.023, 0.047?±?0.004, 0.035?±?0.022, and 0.016?±?0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. T I Ng , et al. Selection and Characterization of Varicella-Zoster Virus Variants Resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine. Antimicrob Agents Chemother. 2001 Jun;45(6):1629-36.

溶解度数据	In Vitro: DMSO : 230 mg/mL (908.16 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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