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CCT007093

目录号: PL04555 纯度: ≥98%

CCT007093 是有效的蛋白磷酸酶 1D (PPM1D Wip1) 的抑制剂。Wip1 的抑制可激活mTORC1 通路，增强肝切除手术后肝细胞的增殖。

CAS No. :176957-55-4

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中文名称	CCT007093
中文别名	(2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮;CCT007093 抑制剂;CCT007093
英文名称	CCT007093
英文别名	CCT007093;(2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one;CCT-007093;(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone;CCTOO7093;(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone;2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone;Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-;(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone;(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone CCT007093;CCT 007093;PPM1D Phosphatase Inhibitor;(2E,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one;C15H12OS2;HMS1434P09;2308AH;s7485;IDI1_012782;BC600545;2,5-Bis(2-thienylmethylene)cyclopentanone;A14289;CCT007093, >=98% (HPLC), powder, yellow
Cas No.	176957-55-4
分子式	C₁₅H₁₂Os₂
分子量	272.39
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	CCT007093 是有效的蛋白磷酸酶 1D (PPM1D Wip1) 的抑制剂。Wip1 的抑制可激活mTORC1 通路，增强肝切除手术后肝细胞的增殖。

产品详情	CCT007093 是有效的蛋白磷酸酶 1D (PPM1D Wip1) 的抑制剂。Wip1 的抑制可激活mTORC1 通路，增强肝切除手术后肝细胞的增殖。
生物活性	CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.
性状	Solid
体外研究(In Vitro)	CCT007093 (25 or 50 μM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line. CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells. CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Lingling Zhang, et al. Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin. Hepatology. 2015 Jun;61(6):2030-41. [2]. S Rayter, et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.

溶解度数据	In Vitro: DMF : 3.33 mg/mL (12.23 mM; Need ultrasonic)DMSO : ≥ 2.8 mg/mL (10.28 mM)

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[1]. Lingling Zhang, et al. Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin. Hepatology. 2015 Jun;61(6):2030-41.
[2]. S Rayter, et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

CCT007093

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