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S65487 hydrochloride

(Synonyms: VOB560 hydrochloride)

目录号: PL03767 纯度: ≥99%

S65487 (VOB560) hydrochloride 是一种有效的选择性 Bcl-2 抑制剂，是 S55746 的前药。S65487 hydrochloride 对 BCL-2 突变也有活性，例如 G101V 和 D103Y。S65487 hydrochloride 对 MCL-1，BFL-1 和 BCL-XL 的亲和力较差。S65487 hydrochloride 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。

CAS No. :1644543-95-2

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PL03767-25mg	25mg	¥28930.00	请登录
PL03767-50mg	50mg	询价	询价
PL03767-100mg	100mg	询价	询价

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中文名称	S65487 hydrochloride
英文名称	S65487 hydrochloride
英文别名	VOB560 HCl;S65487 HCl;BDBM161571;US9108983, Example 386;US9108983, Example 449;NSC834375;S65487 hydrochloride
Cas No.	1644543-95-2
分子式	C₄₁H₄₁ClN₆O₄
分子量	717.26
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	S65487 (VOB560) hydrochloride 是一种有效的选择性 Bcl-2 抑制剂，是 S55746 的前药。S65487 hydrochloride 对 BCL-2 突变也有活性，例如 G101V 和 D103Y。S65487 hydrochloride 对 MCL-1，BFL-1 和 BCL-XL 的亲和力较差。S65487 hydrochloride 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。

产品详情

生物活性

S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities.

性状

Solid

体外研究(In Vitro)

S65487 hydrochloride binds to the BH3 hydrophobic groove of BCL-2. S65487 hydrochloride induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

S65487 hydrochloride induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 hydrochloride in combination with the MCL-1-specific inhibitor, S64315/MIK665. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Arnaud Le Tiran, et al. Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax. Cancer Research. July 2021.

溶解度数据	In Vitro: DMSO : 90 mg/mL (119.41 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

S65487 hydrochloride

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