Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth.

Solid

Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m in PC-3M cells.
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no signi?cant dark cytotoxicity in NCI-h446 cells.
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells.
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner.
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells. has not independently confirmed the accuracy of these methods. They are for reference only.

Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male BALB/c nu

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75(6):644-51.
[2]. Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348(2):413-20.

In Vitro: DMSO : 2.5 mg/mL (4.56 mM; ultrasonic and warming and heat to 60°C)配制储备液