FB23-2 是一种有效、选择性的 mRNA N⁶- 甲基腺嘌呤脱甲基酶 FTO 抑制剂，IC₅₀ 值为 2.6 μM。FB23-2 具有抗增殖作用。FB23-2 能用于急性髓系白血病 (AML) 的研究。

FB23-2 is a potent and selective inhibitor of mRNA N-methyladenosine (mA) demethylase FTO, with an IC 50 of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML).

Solid

IC50: 2.6 μM (FTO)

FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human AML cell line cells and primary blast AML cells.
FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM.
FB23-2 (20 μM; 72 hours) displays anti-proliferation effect via upregulating global mA levels.
FB23-2 (0.5-5 μM; 24-72 hours) significantly suppresses the proliferation of BM cells from these two models in a dose-dependent manner.
FB23-2 exhibits FTO-dependent anti-proliferation activity and promotes myeloid differentiation and apoptosis.
FB23-2 (1-20 μM; 72 hours) significantly increases the mRNA and protein levels of ASB2 and RARA in NB4 and MONOMAC6 cells.
FB23-2 induces apoptosis (1-20 μM; 48-72 hours) and cell cycle arrest (5-20 μM; 24 hours) at G1 stage in AML cells.

FB23-2 (2 mg/kg; i.p.; daily; for 10 days) substantially suppresses leukemia progression and prolongs survival.
FB23-2 exhibits elimination half-life (rat 6.7 h) and C max (rat 2421.3 ng/mL) following intraperitoneal injection (rat 3 mg/kg).
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

[1]. Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.

In Vitro: DMSO : 25 mg/mL (63.74 mM; Need ultrasonic)配制储备液