Mepazine hydrochloride|2975-36-2|(Pecazine hydrochloride)-陌孚医药/Medlife

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Mepazine hydrochloride (Synonyms: Pecazine hydrochloride)

目录号: PL02492 纯度: ≥98%

CAS No. :2975-36-2

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中文名称	Mepazine hydrochloride
中文别名	哌卡嗪盐酸盐;甲哌啶嗪盐酸盐
英文名称	Mepazine hydrochloride
英文别名	10H-Phenothiazine,10-[(1-methyl-3-piperidinyl)methyl]-, hydrochloride (1:1);10-(1-Methyl-[3]piperidylmethyl)-phenothiazin, Hydrochlorid;10-(1-methyl-[3]piperidylmethyl)-phenothiazine, hydrochloride;10-(1-methyl-piperidin-3-ylmethyl)-10H-phenothiazine, monohydrochloride;10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride;10-[(1-methyl-3-piperidyl)methyl]phenothiazine hydrochloride;10-[(1-methyl-3-piperydil)methyl]phenothiazine hydrochloride;mepazine hydrochloride
Cas No.	2975-36-2
分子式	C₁₉H₂₂N₂S^.HCl
分子量	346.92
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC₅₀ 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
生物活性	Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC 50 s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
性状	Solid
IC50 & Target[1][2]	MALT1
体外研究(In Vitro)	Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.

溶解度数据	In Vitro: DMSO : 50 mg/mL (144.13 mM; Need ultrasonic)H₂O : 2.22 mg/mL (6.40 mM; ultrasonic and warming and heat to 60°C)配制储备液

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