MSN-50

目录号: PL02376 纯度: ≥98%
MSN-50 是一种 Bax 和 Bak 寡聚抑制剂。MSN-50 能有效抑制脂质体的通透性,防止基因毒性细胞死亡,促进神经保护。
CAS No. :1592908-75-2
商品编号 规格 价格 会员价 是否有货 数量
PL02376-5mg 5mg ¥15751.00 请登录
PL02376-10mg 10mg ¥24912.00 请登录
PL02376-25mg 25mg ¥49021.00 请登录
PL02376-50mg 50mg ¥78434.00 请登录
PL02376-100mg 100mg ¥125367.00 请登录
PL02376-200mg 200mg 询价 询价
PL02376-500mg 500mg 询价 询价
Medlife所售产品仅用于科学研究(非临床研究),非药品不可食用,不可用于人体或动物的临床诊断和治疗,我们不为个人提供产品及服务。产品COA等资料,可至下方“质量控制”中下载。
*注意事项:下单时请联系销售核实产品价格及货期,避免后续产生不便,感谢支持!
中文名称
MSN-50
英文名称
MSN-50
英文别名
N-{1(S)-[[3(S)-Amino-6-(2-methoxy-ethoxymethoxy)-2,3-dihydro-benzofuran-2(R)-ylmethyl]-(4-bromo-benzyl)-carbamoyl]-2-phenyl-ethyl}-benzamide;N-((S)-1-((((2R,3S)-3-Amino-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide;MSN-50
Cas No.
1592908-75-2
分子式
C36H38BrN3O6
分子量
688.61
包装储存
4°C, stored under nitrogen, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
详情描述
MSN-50 是一种 Bax 和 Bak 寡聚抑制剂。MSN-50 能有效抑制脂质体的通透性,防止基因毒性细胞死亡,促进神经保护。
产品详情
MSN-50 是一种 Bax 和 Bak 寡聚抑制剂。MSN-50 能有效抑制脂质体的通透性,防止基因毒性细胞死亡,促进神经保护。
生物活性
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
性状
Solid
IC50 & Target[1][2]
Bax Bak
体外研究(In Vitro)
MSN-50 (0~10 uM) inhibits dye release from liposomes in a concentration-dependent fashion. MSN-50 (0~40 uM) inhibits tBid/Bax-mediated MOMP (mitochondrial outer membrane permeabilization) in a concentration-dependent manner and shows concentration-dependent inhibition of Bak-mediated MOMP. MSN-50 inhibits both Bax and Bak after activation by either cBid or Bim. MSN-50 (5 μM; BMK cells) inhibits apoptosis induced by actinomycin D and staurosporin (STS). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, stored under nitrogen, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
参考文献
[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24(4):493-506.e5.
[2]. Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood). 2019;244(8):621-629.
溶解度数据
In Vitro: DMSO : 200 mg/mL (290.44 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24(4):493-506.e5.
[2]. Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood). 2019;244(8):621-629.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2