Pitstop 2

目录号: PL02267 纯度: ≥99%
Pitstop 2 是一种网格蛋白抑制剂,可通过与网格蛋白的末端域相关联来抑制网格蛋白介导的内吞作用 (CME)。Pitstop 2 有潜力用于抗癌的研究。
CAS No. :1419320-73-2
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中文名称
Pitstop 2
英文名称
Pitstop 2
英文别名
Pitstop 2
Cas No.
1419320-73-2
分子式
C20H13BrN2O3S2
分子量
473.36
包装储存
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
详情描述
Pitstop 2 是一种网格蛋白抑制剂,可通过与网格蛋白的末端域相关联来抑制网格蛋白介导的内吞作用 (CME)。Pitstop 2 有潜力用于抗癌的研究。
产品详情
Pitstop 2 是一种网格蛋白抑制剂,可通过与网格蛋白的末端域相关联来抑制网格蛋白介导的内吞作用 (CME)。Pitstop 2 有潜力用于抗癌的研究。
生物活性
Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research.
性状
Solid
体外研究(In Vitro)
Pitstop 2 (20-40 μM; 30 min) inhibits the endocytosis of transferrin in J774A.1 macrophages and does not compromise cell viability.
Pitstop 2 (20-40 μM; 30 min) does not affect the internalization of cholera toxin B in J774A.1 macrophages.
Pitstop 2 (0.001-100 μM; 6 h) inhibits the mitotic spindle and impairs mitotic progression in HeLa cells.
Pitstop 2 (1-30 μM; 24 h) induces apoptosis and inhibits cell growth in dividing cancer cells.
Pitstop 2 (1-30 μM; 48 h) does not affect the growth and viability of non-tumourigenic NIH3T3 fibroblasts. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献
[1]. Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9(1): 12636.
[2]. Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.
溶解度数据
In Vitro: DMSO : 62.5 mg/mL (132.03 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9(1): 12636.
[2]. Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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