Z-Asp-CH2-DCB|153088-73-4|-陌孚医药/Medlife

您当前的位置：

Z-Asp-CH2-DCB

目录号: PL02164 纯度: ≥99%

Z-Asp-CH2-DCB 是一种不可逆的广谱 caspase 抑制剂，Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。Z-D-CH2-DCB 并以剂量依赖的方式阻断 PBMC 细胞中的金黄色葡萄球菌肠毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的产生，和降低 SEB-1 刺激的 T 细胞增殖。Z-Asp-CH2-DCB 可预防 SU5416 诱导的间隔细胞凋亡和肺气肿的发生。

CAS No. :153088-73-4

商品编号	规格	价格	会员价
PL02164-1mg	1mg	¥1044.00	请登录
PL02164-5mg	5mg	¥1155.00	请登录
PL02164-10mg	10mg	¥1715.00	请登录
PL02164-50mg	50mg	¥7367.50	请登录
PL02164-10mM*1mLinDMSO	10mM*1mLinDMSO	¥3020.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Z-Asp-CH2-DCB
中文别名	半胱天冬酶-1 抑制剂 V
英文名称	Z-Asp-CH2-DCB
英文别名	Benzoic acid,2,6-dichloro-, (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butylester;"Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE";Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE;Z-Asp-2006-dichlorobenzoyloxymethylketone;Z-Asp-CH2-DCB;ICE INHIBITOR V;ICE INHIBITOR VI;PASE-1 INHIBITOR III;PASE-1 INHIBITOR V;Z-D-CH2-DCB;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;CASPASE-1 INHIBITOR V;Z-Asp-[(2,6-dichlorobenzoyl)oxy]methane;CASPASE-1 INHIBITOR III;Z-L-ASP-ALPHA-[(2,6-DICHLOROBENZOYL)OXY]METHANE
Cas No.	153088-73-4
分子式	C₂₀H₁₇NO₇Cl₂
分子量	454.26
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Z-Asp-CH2-DCB 是一种不可逆的广谱 caspase 抑制剂，Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。Z-D-CH2-DCB 并以剂量依赖的方式阻断 PBMC 细胞中的金黄色葡萄球菌肠毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的产生，和降低 SEB-1 刺激的 T 细胞增殖。Z-Asp-CH2-DCB 可预防 SU5416 诱导的间隔细胞凋亡和肺气肿的发生。
生物活性	Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development.
性状	Solid
体外研究(In Vitro)	Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells. Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (SU5416+ Z-As
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Krakauer T, et al. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4. [2]. Kasahara Y, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9.

溶解度数据	In Vitro: DMSO : 100 mg/mL (220.14 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation