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Tubulin inhibitor 1

目录号: PL02067 纯度: ≥99%

Tubulin inhibitor 1 是 tubulin 抑制剂，靶作用于秋水仙素结合位点，抑制微管蛋白聚集。Tubulin inhibitor 1 具有抗肿瘤活性，能够导致细胞 G2/M 期有丝分裂停滞，诱导细胞凋亡。

CAS No. :2237054-53-2

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PL02067-200mg	200mg	询价	询价
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PL02067-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1719.00	请登录

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中文名称	Tubulin inhibitor 1
英文名称	Tubulin inhibitor 1
英文别名	Tubulin inhibitor 1;4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole;96C
Cas No.	2237054-53-2
分子式	C₂₁H₂₄N₂O₄
分子量	368.43
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Tubulin inhibitor 1 是 tubulin 抑制剂，靶作用于秋水仙素结合位点，抑制微管蛋白聚集。Tubulin inhibitor 1 具有抗肿瘤活性，能够导致细胞 G2/M 期有丝分裂停滞，诱导细胞凋亡。

产品详情	Tubulin inhibitor 1 是 tubulin 抑制剂，靶作用于秋水仙素结合位点，抑制微管蛋白聚集。Tubulin inhibitor 1 具有抗肿瘤活性，能够导致细胞 G2/M 期有丝分裂停滞，诱导细胞凋亡。
生物活性	Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis.
性状	Solid
IC50 & Target[1][2]	Tubulin
体外研究(In Vitro)	Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively. Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Tubulin inhibitor 1 (50 mg/kg, i.p., every two days three times for 20-25 days) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Lai Q, et al. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3. Eur J Med Chem. 2018 Aug 5;156:162-179.

溶解度数据	In Vitro: DMSO : ≥ 125 mg/mL (339.28 mM)配制储备液

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[1]. Lai Q, et al. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3. Eur J Med Chem. 2018 Aug 5;156:162-179.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Tubulin inhibitor 1

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