BLM-IN-1 是一种有效的布卢姆综合征蛋白 (BLM) 抑制剂。BLM-IN-1 具有高结合亲和力，K_D 值为 1.81 μM。BLM-IN-1 对 BLM 具有良好的抑制作用，IC₅₀ 值为 0.95 μM。BLM-IN-1 可诱导细胞凋亡。BLM-IN-1 可用于 DNA 损伤与癌症的研究。

BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a K D valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC 50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer.

Solid

IC50: 0.95 μM (BLM).

BLM-IN-1 (compound 29) has a strong BLM binding with a KD of 1.81 μM.
BLM-IN-1 can inhibit BLM with an IC50 of 0.95 μM.
BLM-IN-1 (1.0 μM) inhibits the unwinding activity of BLM but also disrupt the BLM binding to DNA.
BLM-IN-1 (0-1.0 μM) regulates the homologous recombination by disrupting the recruitment of BLM to DSB sites.
BLM-IN-1 (1.0, 2.0 μM; 48 h) induces DNA damage response and apoptosis.
BLM-IN-1 (0.1, 1.0, 2.0 μM; 48 h) induces proliferation arrest and synthetic interaction. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Blooms Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162.

In Vitro: DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic)配制储备液