Deoxynyboquinone|96748-86-6|-陌孚医药/Medlife

您当前的位置：

Deoxynyboquinone

目录号: PL01717 纯度: ≥99%

CAS No. :96748-86-6

商品编号	规格	价格	会员价
PL01717-1mg	1mg	¥5625.00	请登录
PL01717-5mg	5mg	¥16876.00	请登录
PL01717-10mg	10mg	询价	询价
PL01717-50mg	50mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Deoxynyboquinone
英文名称	Deoxynyboquinone
英文别名	1,4,6-trimethyl-1H,9H-pyrido[3,2-g]quinoline-2,5,8,10-tetraone;1.4.5-Trimethyl-2.7-dioxo-1.8-diaza-anthrachinon;deoxynyboqionone;deoxynyboquinone;DNQ
Cas No.	96748-86-6
分子式	C₁₅H₁₂N₂O₄
分子量	284.27
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Deoxynyboquinone 是 NQO1 的底物，是有效的抗癌剂。Deoxynyboquinone 诱导癌症细胞凋亡 (apoptosis)。Deoxynyboquinone 通过氧化应激和活性氧 (ROS) 的形成杀死癌细胞。
生物活性	Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation.
性状	Solid
IC50 & Target[1][2]	Apoptosis; ROS
体外研究(In Vitro)	Deoxynyboquinone (DNQ; 72h) potently induces the death of cancer cells (SK-MEL-5, MCF-7, HL-60, HL-60/ADR) in culture, with IC50 values between 16 and 210 nM. Deoxynyboquinone is still able to induce cancer cell death under hypoxic conditions (HeLa cell; IC50: 5.1 μM). Deoxynyboquinone (group B1; 0.5 μM; 3, 6, 24 hours) potently induces apoptosis in cancer cell lines (MCF-7, HL-60) through cytochrome c release. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Deoxynyboquinone (2.5, 5, and 10 mg/kg; every other day for 5 injections; i.v. for day 2-18) shows antitumor efficacy confirmed by overall survival (at 5 mg/kg), at a 6-fold lower dose than β-lapachone (30 mg/kg). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Elizabeth I Parkinson, et al. Deoxynyboquinones as NQO1-Activated Cancer Therapeutics. Acc Chem Res. 2015 Oct 20;48(10):2715-23. [2]. Joseph S Bair, et al. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. J Am Chem Soc. 2010 Apr 21;132(15):5469-78. [3]. Tudor G, et,al. Cytotoxic

溶解度数据	In Vitro: DMSO : 4 mg/mL (14.07 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation