ML311

目录号: PL01280 纯度: ≥98%
ML311 是 Mcl-1/Bim 蛋白之间相互作用的有效选择性抑制剂。
CAS No. :315698-17-0
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中文名称
ML311
英文名称
ML311
英文别名
ML311;7-[(4-ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol;ML 311;7-((4-ethylpiperazin-1-yl)(4-(trifluoromethyl)phenyl)methyl)quinolin-8-ol;7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol;7-{(4-ethylpiperazin-1-yl)[4-(trifluoromethyl)phenyl]methyl}quinolin-8-ol;SMR000559037;MLS001198484;MLS004257019;HMS2858D15;BCP32653;STL487150
Cas No.
315698-17-0
分子式
C23H24F3N3O
分子量
415.45
包装储存
Powder -20°C 3 years;4°C 2 years
详情描述
ML311 是 Mcl-1/Bim 蛋白之间相互作用的有效选择性抑制剂。
产品详情
ML311 是 Mcl-1/Bim 蛋白之间相互作用的有效选择性抑制剂。
生物活性
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
性状
Solid
IC50 & Target[1][2]
Mcl-1 Bim
体外研究(In Vitro)
ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.
溶解度数据
In Vitro: DMSO : 67.5 mg/mL (162.47 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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