SEP-363856 hydrochloride|1310422-41-3|(SEP-856 hydrochloride)-陌孚医药/Medlife

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SEP-363856 hydrochloride (Synonyms: SEP-856 hydrochloride)

目录号: PL03547 纯度: ≥99%

CAS No. :1310422-41-3

商品编号	规格	价格	会员价
PL03547-5mg	5mg	¥4821.00	请登录
PL03547-10mg	10mg	¥8036.00	请登录
PL03547-50mg	50mg	¥20090.00	请登录
PL03547-100mg	100mg	询价	询价
PL03547-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5304.00	请登录

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中文名称	SEP-363856 hydrochloride
英文名称	SEP-363856 hydrochloride
英文别名	6P8Y2467AU;5H-Thieno(2,3-C)pyran-7-methanamine, 4,7-dihydro-N-methyl-, hydrochloride (1:1), (7S)-;(S)-1-(5,7-Dihydro-4H-thieno(2,3-C)pyran-7-yl)-N-methylmethanamine hydrochloride;SEP-363856 (hydrochloride);SEP-856 hydrochloride;SEP-363856 hydrochloride
Cas No.	1310422-41-3
分子式	C₉H₁₄ClNOs
分子量	219.73
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

SEP-363856 (SEP-856) hydrochloride 是具有口服活性的、中枢神经系统活性的抗精神病活性化合物，具有研究精神分裂症的潜力。

生物活性

SEP-363856 hydrochloride (SEP-856 hydrochloride), an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride (SEP-856 hydrochloride) has the potential for the study of schizophrenia.

性状

Solid

IC50 & Target[1][2]

TAAR1 0.140 μM (EC50) 5-HT1A Receptor

体外研究(In Vitro)

SEP-856 (10 μM) shows >50% inhibition of specific binding at α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs.
SEP-856 (0.3, 1 and 10 mg/kg, orally once) significantly reduces PCP-induced hyperactivity.
Oral SEP-856 administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Dedic N, et al. SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14.

溶解度数据	In Vitro: H₂O : 100 mg/mL (455.10 mM; Need ultrasonic)DMSO : 62.5 mg/mL (284.44 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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