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L-Leucine-7-amido-4-methylcoumarin hydrochloride

(Synonyms: Leu-AMC hydrochloride)

目录号: PL14091 纯度: ≥99%

L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride 是 LAP3 c亮氨酸氨基肽酶的蓝色荧光肽基底物。L-Leucine-7-amido-4-methylcoumarin hydrochloride 可用于亮氨酸氨基肽酶抑制实验。

CAS No. :62480-44-8

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中文名称	L-Leucine-7-amido-4-methylcoumarin hydrochloride
中文别名	(2S)-2-氨基-4-甲基-N-(4-甲基-2-氧代-2H-1-苯并吡喃-7-基)-戊酰胺单盐酸盐;1,2-二软酯酰基蛋黄素;L-亮氨酸-7-氨基-4-甲基香豆素盐酸盐;L-亮氨酸-7-酰氨基-4-甲基香豆素盐酸盐;L-亮氨酰-7-氨基-4-甲基香豆素盐酸盐;L-亮氨酰7-氨基-4-甲基香豆素盐酸盐;(S)-2-氨基-4-甲基-N-(4-甲基-2-氧代-2H-1-苯并吡喃-7-基)戊酰胺单盐酸盐
英文名称	L-Leucine-7-amido-4-methylcoumarin hydrochloride
英文别名	(S)-2-Amino-3-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)butanamide hydrochloride;(2S)-2-Amino-4-Methyl-N-(4-Methyl-2-Oxo-2H-1-Benzopyran-7-Yl)-Pentanamide Monohydrochloride;2-amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide,hydrochloride;AMINOPEPTIDASE SUBSTRATE I;L-Leucine-(4-methyl-7-coumarinylamide) hydrochloride;L-Leucine-7-amido-4-methylcoumarin hydrochloride;NULL;Pentanamide,2-amino-4-methyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, monohydrochloride,(2S)- (9CI);Pentanamide,2-amino-4-methyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, monohydrochloride,(2S)-...;H-L-LEU-AMC HCL;L-Leucine 7-amido-4-methylcoumarin hydrochloride;L-Leucine-7-amino-4-methylcoumarin hydrochloride;(2S)-2-amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide;hydrochloride;(S)-2-amino-4-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide hydrochloride;L-Leucine-7-amido-4-methylcoumarin (hydrochloride);L-Leucine 7-amido-4-methylcoumarin hydrochloride salt;Leu-AMC;Leu-AMC HCl;H-Leu-AMC hydrochloride;C16H20N2O3.HCl;SCH
Cas No.	62480-44-8
分子式	C₁₆H₂₁ClN₂O₃
分子量	324.80
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride 是 LAP3 c亮氨酸氨基肽酶的蓝色荧光肽基底物。L-Leucine-7-amido-4-methylcoumarin hydrochloride 可用于亮氨酸氨基肽酶抑制实验。

产品详情	L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride 是 LAP3 c亮氨酸氨基肽酶的蓝色荧光肽基底物。L-Leucine-7-amido-4-methylcoumarin hydrochloride 可用于亮氨酸氨基肽酶抑制实验。
生物活性	L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro.
性状	Solid
体外研究(In Vitro)	In leucine aminopeptidases inhibition assays in KB 3.1 cells. Compounds 3 and 5 are observed to weakly inhibit the biofilm formation by S. aureus and constrain inhibitory activity of ?-Leu-AMC hydrolysis in KB 3.1 cells. The amount of hydrolyzed 7-amino-4-methylcoumarin (AMC) is determined in a fluorescence spectrophotometer (excitation/emission: 365/440 nm). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Tian Cheng, et al. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem

溶解度数据	In Vitro: DMSO : 100 mg/mL (307.88 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

[1]. Tian Cheng, et al. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

L-Leucine-7-amido-4-methylcoumarin hydrochloride

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