EPQpYEEIPIYL|147612-86-0|-陌孚医药/Medlife

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EPQpYEEIPIYL

目录号: PL11445 纯度: ≥98%

EPQpYEEIPIYL 是一种磷酸肽，是 Src 同源 2 (SH2) 结构域配体。 EPQpYEEIPIYL 通过与 SH2 域结合来激活 Src 家族成员 (例如 Lck，Hck，Fyn)。

CAS No. :147612-86-0

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中文名称	EPQpYEEIPIYL
英文名称	EPQpYEEIPIYL
英文别名	H-Glu-Pro-Gln-Tyr(PO?H?)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH;H-Glu-Pro-Gln-Tyr(PO₃H₂)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH;(pY)EEI;YEEI PEPTIDE;EPQ-PY-EEIPIYL*;SH2 DOMAIN LIGAND (2);GLU-PRO-GLN-PTYR-GLU-GLU-ILE-PRO-ILE-TYR-LEU;H-GLU-PRO-GLN-PTYR-GLU-GLU-ILE-PRO-ILE-TYR-LEU-OH;YEEI Peptide, Phosphorylated trifluoroacetate salt;GLU-PRO-GLN-TYR(PO3H2)-GLU-GLU-ILE-PRO-ILE-TYR-LEU;H-GLU-PRO-GLN-TYR(H2PO3)-GLU-GLU-ILE-PRO-ILE-TYR-LEU-OH;BDBM50289749;L-Glu-L-Pro-L-Gln-O-Phosphono-L-Tyr-L-Glu-L-Glu-L-Ile-L-Pro-L-Ile-L-Tyr-L-Leu-OH;(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-1;H-GLU-PRO-GLN-TYR(PO3H2)-GLU-GLU-ILE-PRO-ILE-TYR-LEU-OH
Cas No.	147612-86-0
分子式	C₆₆H₉₇N₁₂O₂₄P
分子量	1473.52
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	EPQpYEEIPIYL 是一种磷酸肽，是 Src 同源 2 (SH2) 结构域配体。 EPQpYEEIPIYL 通过与 SH2 域结合来激活 Src 家族成员 (例如 Lck，Hck，Fyn)。
生物活性	EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains.
性状	Solid
体外研究(In Vitro)	The hmT-derived phosphopeptide, pY324, which has the sequence EPQpYEEIPIYL, shows the highest affinity binding to GST fusion proteins of the Lck SH2 domain (5-fold higher than Lck’s affinity-for the Lck tail phosphopeptide) and the Src SH2 domain (44-fold higher than Src’s affinity for the Src tail phosphopeptide). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	EPQpYEEIPIYL
参考文献	[1]. G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1(2):99-105. [2]. T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5(10):1313-23.

溶解度数据	In Vitro: H₂O : 2 mg/mL (1.36 mM; ultrasonic and adjust pH to 2 with HCl)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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