MK-2894 sodium salt 是一种有效的、选择性的、具有口服活性的高亲和力 (K_i=0.56 nM) 的前列腺素受体 4 (EP₄ receptor) 的拮抗剂 (IC₅₀=2.5 nM)。MK-2894 sodium salt 在动物疼痛/炎症模型中具有较强的抗炎活性，可用于关节炎的研究。

MK-2894 sodium salt is a potent, selective, orally active and high affinity (K i =0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC 50 =2.5 nM). MK-2894 sodium salt possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis.

Solid

MK-2894 sodium salt (oral administration, 20 mg/kg; intravenous injection, 5 mg/kg) exhibits a favorable pharmacokinetic profile in mice, the moderate bioavailability F=21%, and slow to moderate clearance rate (CL=23 mL/min/kg), the volume of distribution (V dss =7.6 L/kg), good elimination half-lives (T 1/2 =15 h) and the maximum concentration reached (C max =1.4 μM) in mice.
MK-2894 sodium salt (oral administration, 20 mg/kg; intravenous injection, 5 mg/kg) exhibits a favorable pharmacokinetic profile in SD-rats, the moderate bioavailability F=29%, and slow to moderate clearance rate (CL=9.2 mL/min/kg), the volume of distribution (V dss =2.6 L/kg), good elimination half-lives (T 1/2 =4.5 h) and the maximum concentration reached (C max =4.5 μM) in mice.
MK-2894 sodium salt (oral administration, 5 mg/kg;

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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