GSK-269984A|892664-04-9|-陌孚医药/Medlife

您当前的位置：

GSK-269984A

目录号: PL10139 纯度: ≥99%

CAS No. :892664-04-9

商品编号	规格	价格	会员价
PL10139-5mg	5mg	¥7232.00	请登录
PL10139-10mg	10mg	¥12858.00	请登录
PL10139-50mg	50mg	询价	询价
PL10139-100mg	100mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	GSK-269984A
英文名称	GSK-269984A
英文别名	GSK-269984A;sodium,6-[[5-chloro-2-[(4-chloro-2-fluorophenyl)methoxy]phenyl]methyl]pyridine-2-carboxylate
Cas No.	892664-04-9
分子式	C₂₀H₁₃NO₃FCl₂-^.Na+
分子量	428.22
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	GSK-269984A 是前列腺素 E2 受体 1 (Prostaglandin E2 Receptor 1 (EP1)) 的拮抗剂，pIC₅₀ 值为 7.9。
生物活性	GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC 50 of 7.9.
性状	Solid
IC50 & Target[1][2]	pIC50: 7.9 (Prostaglandin E2 Receptor 1 (EP1))
体外研究(In Vitro)	Results from [H]-PGE2 binding assay in CHO cells overexpressing the human EP1 receptor demonstrate that GSK-269984A is an antagonist of EP1 receptor with a pIC50 of 7.9. GSK-269984A is found to cause a concentration-dependent rightward shift of the PGE2 dose-response curve and Schild analysis shows that GSK-269984A is a competitive antagonist with pA2 8.1±0.3 and slope 1.0. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	GSK-269984A demonstrates an ED 50 of 2.6 mg/kg (po), with the 10 mg/kg dose showing equivalent reversal of hypersensitivity to the standard. GSK-269984A displays moderate blood clearance in the rat and dog and high clearance in the monkey which is reflected in the half-life for each species. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Hall A, et al. Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2009 May 1;19(9):2599-603.

溶解度数据	In Vitro: DMSO : 7 mg/mL (16.31 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation